Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias.

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Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias.

BACKGROUND Although the existence of myocardial mechanoelectrical feedback is well established, the mechanism of arrhythmia induction by ventricular dilatation or stretch remains insufficiently defined. In particular, controversy exists when comparing the arrhythmogenic potential of chronic versus acute myocardial stretch. Also, assessment of cellular electrophysiological effects of myocardial ...

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Stretch-Activated Arrhythmias

Background. Although the existence of myocardial mechanoelectrical feedback is well established, the mechanism of arrhythmia induction by ventricular dilatation or stretch remains insuffliciently defined. In particular, controversy exists when comparing the arrhythmogenic potential of chronic versus acute myocardial stretch. Also, assessment of cellular electrophysiological effects of myocardia...

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AMP-activated protein kinase (AMPK) protects various tissues and cells from ischemic insults and is activated by many stimuli including mechanical stretch. Therefore, this study investigated if the activation of AMPK is involved in stretch-induced cardioprotection (SIC). Intraventricular balloon and aorto-caval shunt (ACS) were used to stretch rat hearts ex vivo and in vivo, respectively. Stret...

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On Stretch curvature of Finsler manifolds

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ژورنال

عنوان ژورنال: Circulation

سال: 1992

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.86.3.968